Maximum Standardized Uptake Values on Positron Emission Tomography Correlates with Iaslc/Ats/Ers Histologic Subtypes and Prognosis of Clinical Stage Ia Lung Adenocarcinoma

Abstract

ABSTRACT Aim: High maximum standardized uptake values (SUVmax) on [18F]-fluoro-2-deoxyglucose positron emission tomography (FDG-PET) have been demonstrated to be associated with inferior survival in lung adenocarcinoma. In this study, we investigated the association between SUVmax and the IASLC/ATS/ERS histologic subtypes of clinical stage IA lung adenocarcinoma. Methods: We retrospectively examined 347 consecutive patients with clinical stage IA lung adenocarcinoma who underwent complete resection. The percentage of each histological component was recorded. Patients were classified by the predominant histologic grade and solid/micropapillary (S/Mp) component ratio in the tumour. Results: The mean (± SD) SUVmax of all patients was 2.31 ± 2.46. A total of 180 tumours (53%) had low-grade histology (38 adenocarcinoma in situ, 12 minimally invasive adenocarcinoma, and 130 lepidic predominant), 131 (38%) had intermediate-grade histology (70 papillary, 61 acinar predominant), and 36 (11%) had high-grade histology (30 solid, 6 Mp predominant). Thirty-nine (11%), 71 (20%), and 237 (68%) patients had high (>40%), intermediate (5-40%), and low ( Conclusions: SUVmax on PET is strongly associated with histologic classification and S/Mp ratio in lung tumours. SUVmax and predominant subtypes, especially the S/Mp ratio, have strong biologic implications in clinical stage IA lung adenocarcinoma. Disclosure: All authors have declared no conflicts of interest.