Abstract
Materials/Methods: Patients were treated with SBRT for medically inoperable non-small cell lung cancer or metastatic lung lesions at Mayo Clinic from January 11, 2008 to January 12, 2010. Treatment planning was performed with full body immobilization, 4-dimensional CT-based planning and daily cone-beam CT for image guidance. Tissue heterogeneity corrections were used in all cases. Dosimetric data was collected prospectively on all patients. Follow-up care consisted of CT imaging and clinical exam every 3 months. The incidence of radiation pneumonitis (RP) was evaluated and graded according to CTCAE v3.0. The impact of demographic and dosimetric variables on the risk of RP . grade 2 was estimated using Cox proportional hazards regression modeling.
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