Abstract
Some relationships between the estimates of recombination fraction in two-point linkage analysis obtained by maximum likelihood, minimum chi-square, and general least squares are derived. These theoretical results are based on an approximation for the multinomial distribution. Applications (theoretical and experimental) with RFLP (restriction fragment length polymorphism) markers for a segregating F2 population are given. The minimum chi-square estimate is slightly larger than the maximum likelihood estimate. For applications, however, both estimates must be considered to be approximately equal. The least squares estimates are slightly different (larger or smaller) from these estimates.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
