Abstract
Abstract It has been suggested that patients with chronic obstructive chest disease have greater maximal gastric secretion than normal subjects. This problem was studied in 30 subjects using the histamine infusion test with phenol red as a marker to correct for pyloric loss. Clinical, radiological, and physiological criteria were used to define two groups: (1) 13 subjects with normal chests; (2) 14 subjects with unequivocal chronic airway obstruction. The two groups did not differ significantly in maximal gastric secretion, and this conclusion was not altered by taking stature into account because stature was statistically comparable in the two groups. However, age was significantly different and correction of the secretory data for the diminution of maximal secretion with age improved the correspondence between the groups. The failure to take stature and age into account may be responsible for conflicting evidence in the past.
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