Maxillary Swelling as the First Evidence of Multiple Myeloma.

Atsushi Kasamatsu,Yasushi Kimura,Hideki Tsujimura,Harusachi Kanazawa,Hideki Tanzawa,Nao Koide,Isao Miyamoto,Katsuhiro Uzawa,Masashi Shiiba,Yosuke Endo-Sakamoto

doi:10.1155/2015/439536

Abstract

Multiple myeloma is a malignant neoplasm of plasma cells characterized by proliferation of a single clone of abnormal immunoglobulin-secreting plasma cells. Since the amount of hemopoietic bone marrow is decreased in the maxilla, oral manifestations of multiple myeloma are less common in the maxilla than in the mandible. We report the case of 33-year-old Japanese man who presented with a mass in the right maxillary alveolar region. Computed tomography and magnetic resonance images showed a soft tissue mass in the right maxilla eroding the anterior and lateral walls of the maxillary sinus and extending into the buccal space. The biopsy results, imaging, and laboratory investigations led to the diagnosis of multiple myeloma. This case report suggests that oral surgeons and dentists should properly address oral manifestations as first indications of multiple myeloma.

Highlights

Multiple myeloma, a malignant neoplasm of plasma cells, is the most common primary bone malignancy characterized by monoclonal proliferation of plasma cells [1, 2]
We describe a case of multiple myeloma involving the maxilla in a 33-year-old man who experienced swelling with mobility of the teeth in the right maxillary alveolar region
Multiple myeloma accounts for 1% of all malignancies and slightly more than 10% of hematologic malignancies [5]

Summary

Introduction

A malignant neoplasm of plasma cells, is the most common primary bone malignancy characterized by monoclonal proliferation of plasma cells [1, 2]. The clinical manifestations of the disease occur due to an expanding mass of plasma cells in the bone marrow [4]. The most common clinical signs and symptoms of multiple myeloma include renal failure, bone pain, fatigue, anemia, hypercalcemia, and infectious diseases [4, 5]. Oral manifestations of multiple myeloma very rarely present as the initial signs [6]. Few case reports of multiple myeloma with maxillary involvement have been published. We describe a case of multiple myeloma involving the maxilla in a 33-year-old man who experienced swelling with mobility of the teeth in the right maxillary alveolar region

Case Report

Findings

Discussion