Maud L. Menten: Pioneering Physician and Biochemist.

Abstract

Dr. Maud Leanora Menten, an esteemed Canadian physician, biochemist, and organic chemist, conducted a wide range of valuable biochemistry research for over 40 years, making groundbreaking discoveries about cancer treatments, enzyme kinematics, anesthesia medicine, bacterial toxins, vitamin deficiencies, hematology, and histochemistry. Menten demonstrated intense perseverance and tenacity in her education, defying societal norms to not only become one of the first Canadian women to earn a research-intensive Doctor of Medicine (MD) degree, but to also be one of the first to earn a PhD. Although she was restricted in her work in Canada, she moved to the U.S. and published an estimated 100 research studies over her career. She is most well known for her work with Dr. Leonor Michaelis, with whom she created the Michaelis-Menten equation for the relationship between reaction rate and enzyme-substrate concentration. However, she conducted many other noteworthy research projects, such as using radium bromide for cancer treatment in rats and using electrophoretic mobility to study human hemoglobin, which allowed for a more advanced protein analysis. Her research in hemoglobinpreceded the findings of Linus Pauling by several years, however, he is often the only one credited for this work. After her death, the extent and depth of her work was better understood and appreciated by many, and she was recognized byher alma mater, the University of Toronto, and her former workplace, the University of Pittsburgh. She was also posthumously inducted into the Canadian Medical Hall of Fame.