Maturational trends of EEG-sleep measures in the healthy preterm neonate

Abstract

Five physiologic groupings of 45 EEG-sleep measures were acquired from serial 24-channel EEG-sleep recordings (i.e., sleep architecture, continuity, EEG spectral, phasic, and autonomic measures), utilizing 129 studies on 56 healthy preterm infants from 28 to 43 weeks postconceptional age (PCA) who were neurodevelopmentally normal on follow-up. Regression analyses chose the least number of measures that best reflected maturation. Four of 45 variables (i.e., spectral α energy during quiet sleep, total spectral EEG energy, arousal number during active sleep, and percentage of EEG discontinuity) most significantly explained brain maturation in neonates <36 weeks PCA. Three of 45 variables (i.e., spectral θ and β energies during active sleep and spectral α energy during quiet sleep) were most representative after 36 weeks PCA. Spectral EEG energies were the strongest indicators of maturation compared with other measures, particularly in near-term neonates.