Abstract
Overall renal function is thought to increase during development, but it is unclear if a continuum of changes occurs during as well as after nephrogenesis (2½-3 weeks in rabbit). In previous studies (AJP,1983) we found no change in BLM characteristics in outer cortical proximal convoluted tubules (PCT) during nephrogenesis. This finding is not surprising since tubules from the outer nephrogenic zone are of similar maturity even with advancing age. We therefore studied juxtamedullary (JM) tubules to look for developmental changes in the BLM from more mature tubules. 65 early collapsed JMPCT were tightly crimped with micropipets. Changes in cell volume, assessed by measuring outer diameter with an image splitting eyepiece, were used to measure rate of trans BLM fluid movement as tubule volume increased in 10−4 M ouabain. Results are M±SE.
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