Abstract
1. 1. Penicillin is an effective epileptogenic agent in neonatal rabbits. 2. 2. Newborn rabbit's cerebral cortex possesses a definite but limited capacity to produce epileptiform activity. 3. 3. The main characteristic of newborn cerebral cortex in response to penicillin is a marked variability in duration of the paroxysmal activity. 4. 4. Maturation of epileptiform activity shows a time course consistent with increased neuronal hypersynchrony reaching adult spike characteristics by the third post-natal week. 5. 5. The epileptogenic focus in the newborn rabbit projects to the contralateral hemisphere in a limited, inconstant manner during the first post-natal week. The capacity to sustain an electrographic seizure discharge develops by the second post-natal week.
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