Abstract
Growing mouse oocytes incompetent to resume meiosis were fused with fully grown immature mouse oocytes and cultured for 20–24 h. In giant cells that developed, two intact germinal vesicles remained well conserved in all cases. We propose that the cytoplasm of growing oocytes possesses a maturation-inhibiting activity which is able to arrest, after fusion, nuclear maturation in fully grown oocytes competent to mature spontaneously.
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