Matrix solid-phase dispersion of organic compounds and its feasibility for extracting inorganic and organometallic compounds

Abstract

Matrix solid-phase dispersion (MSPD) has been designed and classically used for organic compound purification and extraction. It offers fast, efficient sample pre-treatment for solid, semi-solid, viscous and liquid samples, when compared to traditional extraction methods. Its main advantages are flexibility, selectivity, and the possibility of performing extraction and clean up in one step, resulting in rapid pre-treatment and low solvent consumption. We give an overview of MSPD applied to extracting organic compounds, and assess the feasibility of MSPD for extracting organometallic compounds [arsenobetaine (AsB) and dimethylarsonic acid (DMA)], inorganic antimony species [Sb(III) and Sb(V)] and bromide and iodide. We subjected several Certified Reference Materials (CRMs) (e.g., DORM-2 Dogfish Muscle, BCR-627 Tuna Fish Tissue, and PACS-2 Marine Sediment) and an edible seaweed sample (Kombu, Laminaria ochroleuca) to MSPD by testing different solid supports and eluting solutions. Inductively coupled plasma mass spectrometry (ICP-MS), high-performance liquid chromatography combined with ICP-MS (HPLC-ICP-MS) and HPLC combined with hydride generation atomic fluorescence spectrometry (HPLC-HG-AFS) have been used for bromide and iodide, arsenical organometallic compounds, and inorganic antimony, respectively. We found that MSPD can extract total arsenic and certain arsenic compounds (AsB and DMA) from seafood, halides from seaweed and antimony from marine sediments.