Abstract
The importance of influenza viruses as worldwide infectious agents is well recognized. Specific mutations and evolution in influenza viruses is difficult to predict. We studied specific mutations in matrix protein 1 (M1) of H5N1 influenza A virus together with properties associated with it using prediction tools developed in Bioinformatics. Changes in hydrophobicity, polarity and secondary structure at the site of mutation were noticed and documented to gain insight towards its infection.
Highlights
Continuous outbreaks of the highly pathogenic H5N1 avian influenza A in Asia has resulted in an urgent effort to improve current diagnostics tools to aid containment of the virus and lower the threat of a influenza pandemic
The influenza A virus matrix protein 1 (M1) protein is the most abundant structural component of the virion, and electron microscopy studies of influenza virus A particles show that M1 forms a shell at the internal surface of the viral membrane. [5, 6, 7] The functions of M1 have been studied extensively, and it has been implicated in a variety of roles in the virus life cycle that include RNA and RNP binding [8,9,10,11,12,13,14,15,16], transcription inhibition [9, 10, 14, 17, 18], and control of RNP nuclear import and export. [19,20,21,22,23,24] the matrix protein (M1) of influenza virus plays an essential role in viral replication. [25]
Sequence analysis and hydropathy The M1 sequences from different strains were compared using the computer program MAP MUTATION
Summary
Continuous outbreaks of the highly pathogenic H5N1 avian influenza A in Asia has resulted in an urgent effort to improve current diagnostics tools to aid containment of the virus and lower the threat of a influenza pandemic. In addition to containment procedures, detection of the cause of changes in the viral genome plays an important role in controlling the spread of the virus. Methodology: Sequence analysis Matrix protein (M1) of Influenza A virus sub-type A/Hatay/2004/ (H5N1) Continuous outbreaks of the highly pathogenic H5N1 avian influenza A in Asia has resulted in an urgent effort to improve current diagnostics tools to aid containment of the virus and lower the threat of a influenza (H5N1). Secondary structure prediction Secondary structures were predicted using NNPREDICT. [30] Motif Search: Domains or motifs were searched using ScanProsite at the Expasy Server. [31] Motifs with high probability of occurrence were included in the search
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
