Abstract
BackgroundSeveral studies have reported the association between polymorphisms in Matrix metalloproteinases (MMPs) gene family and risk of Multiple sclerosis (MS). However, the results have been inconsistent and inconclusive. To resolve this issue, here we performed a systematic review and meta-analysis of the MMP-91562 C/T (rs3918242), MMP-3 (− 1612 5A/6A), and MMP-2 (− 1306 C/T) polymorphisms and susceptibility to MS.MethodsWe conducted a comprehensive systematic search in the major electronic database, including Scopus and PubMed to look up for relevant studies published before December 2019 that surveyed the association between the MMP-91562 C/T (rs3918242), MMP-3 (− 1612 5A/6A), and MMP-2 (− 1306 C/T) polymorphisms and susceptibility to MS. The level of association between the polymorphisms and susceptibility to MS in the polled analysis was determined by calculating the odds ratio (OR) and the corresponding 95% confidence interval (CI).ResultsWe found 15 studies containing 2430 MS subjects and 2304 controls. A statistically significant association was observed in the all five comparisons of the MMP-91562 C/T polymorphism and MS risk as follows: dominant model (OR = 1.62, 95% CI = 1.03–2.53, P = 0.03), recessive model (OR = 2.69, 95% CI = 1.68–4.29, P < 0.001), allelic model (OR = 1.51, 95% CI = 1–2.28, P = 0.04), TT vs. CC model (OR = 3.20, 95% CI = 1.87–5.46, P < 0.001), and CT vs. CC model (OR = 1.53, 95% CI = 1.02–2.28, P = 0.04).ConclusionsOur meta-analysis revealed significant association of MMP-9 (− 1562 C/T) Single-nucleotide polymorphism (SNP) with MS susceptibility that increased the disease risk.
Highlights
Several studies have reported the association between polymorphisms in Matrix metalloproteinases (MMPs) gene family and risk of Multiple sclerosis (MS)
Mohammadhosayni et al BMC Neurology (2020) 20:218 studies, several genes, including interleukin (IL) 6, IL-12, vitamin D receptor (VDR), Signal transducer and activator of transcription (STAT) 4, Protein tyrosine phosphatase, non-receptor type 22 (PTPN22), CD40, programmed cell death (PD1/PD-L1), and Matrix metalloproteinases (MMPs) have been correlated with MS and attracted much attention to investigating more genetic factors contributing to MS risk [10,11,12,13,14,15,16,17]
On the basis of structure and in terms of substrate specificity, MMPs are divided into six groups: collagenases (MMP-1, − 8, − 13, − 18), gelatinases (MMP-2, − 9), stromelysins (MMP-3, − 10, − 11), matrilysins (MMP-7, − 26), membrane-type MMPs (MMP-14, − 15, − 16, − 17,24, − 25) and other non-classified MMPs (MMP-12, − 19, − 20, − 21, − 22, − 23, − 27, − 28) that is encoded by a separate gene and has a different tissue distribution and bioactive function [20,21,22]
Summary
Several studies have reported the association between polymorphisms in Matrix metalloproteinases (MMPs) gene family and risk of Multiple sclerosis (MS). The results have been inconsistent and inconclusive To resolve this issue, here we performed a systematic review and meta-analysis of the MMP-91562 C/T (rs3918242), MMP-3 (− 1612 5A/6A), and MMP-2 (− 1306 C/T) polymorphisms and susceptibility to MS. Mohammadhosayni et al BMC Neurology (2020) 20:218 studies, several genes, including interleukin (IL) 6, IL-12, vitamin D receptor (VDR), Signal transducer and activator of transcription (STAT) 4, Protein tyrosine phosphatase, non-receptor type 22 (PTPN22), CD40, programmed cell death (PD1/PD-L1), and Matrix metalloproteinases (MMPs) have been correlated with MS and attracted much attention to investigating more genetic factors contributing to MS risk [10,11,12,13,14,15,16,17]. Several studies have evaluated the association between MMP family gene polymorphisms and MS risk; but the results are often inconsistent [27,28,29]. We performed a meta-analysis to attain a consistent conclusion of the association between the MMP-91562 C/T (rs3918242), MMP-3 (− 1612 5A/6A), and MMP-2 (− 1306 C/T) gene polymorphisms and susceptibility to MS
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