Abstract
Summary BeWo and JAr choriocarcinoma cell lines were used to study cell adhesion and proteolysis, properties thought to be relevant during invasion of maternal decidua by first trimester extravillous trophoblast cells. Both cell lines adhere and spread efficiently on fibronectin, a major component of decidual ECMs. In contrast, they differ by their capacity to interact with laminin and types-I and -IV collagens, which constitute a good substrate for BeWo cells only. These differences are mirrored by the integrin profiles of these cells. BeWo cells express α2β1, α3β1, α5β1, and α6β4 integrins, a profile displayed in vivo by proliferating cytotrophoblast cells during their progression through
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