Matrix metalloproteinase7 -181A/G polymorphism is associated with increased cancer risk among high-quality studies: Evidence from a meta-analysis

Abstract

ObjectivesTo evaluate the effect of Matrix metalloproteinase 7 -181A/G polymorphism (rs11568818) on the risk of cancer, we performed a meta-analysis. Design and methods24 case-control studies were identified by searching Pubmed, Embase, ISI, OVID MEDLINE and EBSCO databases. Odd ratios and corresponding 95% confidence intervals were applied to assess the strength of association between MMP7 -181A/G polymorphism and cancer risk. ResultsBetween MMP7 -181GG genotype and cancer risk, statistically significant association could be observed from overall cancer risk, evidently noted in Asians, observed in high-quality subgroup, and apparently witnessed in PCR-RFLP genotyping subgroup. ConclusionsOur meta-analysis indicates that MMP7 -181GG genotype is associated with overall cancer risk in Asian populations (especially China and India) among high-quality studies.