Abstract
Nowadays, Breast cancer is recognized as the most common cancer among women worldwide. Matrix metalloproteinases (MMPs) are a group of endopeptidase enzymes that can degrade extracellular matrix proteins and increase invasion and metastasis. The purpose of this study was to evaluate the expression of MMP1 and MMP9 genes in breast cancer tissue. In the present case-control study, 90 breast tissue sample, includes 45 breast cancer tissue samples as case group and 45 healthy breast tissue samples as control group were studied. After RNA extraction and cDNA synthesis, MMP1 and MMP9 genes mRNA expression levels were evaluated using Real-Time PCR. In the present study, a significant increase was observed in the expression levels of MMP1 and MMP9 genes mRNA expression in breast cancer tissues compared to normal peripheral tissues. The mRNA expression levels of MMP1 and MMP9 genes in breast cancer tissue were increased by 2.5 and 2.8 fold, respectively. Due to the increased expression of MMP1 and MMP9 genes in breast cancer tissue samples, these proteins can be used as diagnostic markers and novel therapeutic targets. However, further studies with larger sample sizes and on other MMPs are recommended.
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