Abstract
Atherosclerosis as a main etiopathogenetic source for coronary artery disease (CAD) development is intimately related to dynamic changes in the extracellular matrix (ECM). Elevated levels of MMP-13 have been observed in human atherosclerotic plaques which could also involve variability in MMP-13 gene. The aim of the study was to associate rs640198 polymorphism with CAD and/or with its severity.The study comprised 1071 consecutive patients with suspected or known coronary artery disease (CAD), confirmed by coronary angiography.Genotyping for the rs640198 polymorphism in MMP-13 gene was performed using Taqman® assay. The TT and TG genotypes of rs640198 polymorphism in MMP-13 gene confer the significantly increased risk of triple vessel disease compared to patients without atherosclerotic lesions in coronary arteries (odds ratio = 1.64, Pcorr = 0.05). Furthermore, an increased risk of having 5 and more stenoses (odds ratio = 1.90, Pcorr = 0.004) was observed in TT and TG carriers (sensitivity of 0.613 and a specificity of 0.544; power of the test is 0.87).The T allele of MMP-13 intron polymorphism rs640198 is associated with the severity of coronary artery disease, represented by the number of affected arteries as well as by the number of stenoses confirmed by coronarography.
Highlights
The cardiovascular diseases, especially the coronary artery disease (CAD), represent one of the most common causes of mortality in developed countries
Matrix metalloproteinases (MMPs) which are able to cleave collagens should play an important role in the pathogenesis of atherosclerosis, plaque rupture and aneurysm [16,21]
Basic description of the study cohort according to the genotyped of investigated polymorphism is given in Table 1, we found a marginally significant differ
Summary
The cardiovascular diseases, especially the coronary artery disease (CAD), represent one of the most common causes of mortality in developed countries. Atherosclerotic process as a base for CAD onset is intimately related to dynamic changes in the extracellular matrix (ECM) and its associated proteins: the re- Prof. Matrix metalloproteinases (MMPs) which are able to cleave collagens should play an important role in the pathogenesis of atherosclerosis, plaque rupture and aneurysm [16,21]. The expression of various MMPs, along with their endogenous inhibitors, seems to be differentially regulated dependently on the lesion progression [30]
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