Matrix‐mediated mechanical regulation of tissue morphogenesis (79.1)

Abstract

Tissues develop into their mature three‐dimensional (3D) forms via the process of morphogenesis. Using lithographic approaches in combination with 3D traction force microscopy, we have elucidated the mechanical forces required for morphogenesis of the airways of the vertebrate lung, as well as the forces exerted by the airway epithelium as it branches into its characteristic tree‐like structure. I will describe how we combine these experimental strategies with computational approaches to define the mechanical regulation of branching morphogenesis. I will also discuss efforts into understanding the evolutionary relationships between mechanical forces and biochemical signals across a variety of branched organs and species.