Abstract
Matrine is an alkaloid isolated from the traditional Chinese medicine Sophora flavescens Aiton. At present, a large number of studies have proved that matrine has an anticancer effect can inhibit cancer cell proliferation, arrest cell cycle, induce apoptosis, and inhibit cancer cell metastasis. It also has the effect of reversing anticancer drug resistance and reducing the toxicity of anticancer drugs. In addition, studies have reported that matrine has a therapeutic effect on Alzheimer's syndrome, encephalomyelitis, asthma, myocardial ischemia, rheumatoid arthritis, osteoporosis, and the like, and its mechanism is mainly related to the inhibition of inflammatory response and apoptosis. Its treatable disease spectrum spans multiple systems such as the nervous system, circulatory system, and immune system. The antidisease effect and mechanism of matrine are diverse, so it has high research value. This review summarizes recent studies on the pharmacological mechanism of matrine, with a view to providing reference for subsequent research.
Highlights
Traditional Chinese medicine Kushen is the dry root of the leguminous plant Sophora flavescens Aiton, which has a long history of medicinal use in China
The results showed that matrine inhibited cell proliferation, migration, and invasion through Forkhead box protein O (FoxO) and phosphatidylinositol 3-kinase (PI3K)/ AKT signaling pathways
Zhao et al reported that matrine can alleviate apoptosis of cardiac microvascular endothelial cells (CMECs) induced by ischemia/reperfusion, which is related to JAK2/ STAT3 signaling pathway (Zhao et al, 2018)
Summary
Traditional Chinese medicine Kushen is the dry root of the leguminous plant Sophora flavescens Aiton, which has a long history of medicinal use in China. Matrine can regulate Wnt/b-catenin signaling pathway, inhibit the expression of VEGF, thereby inhibiting the proliferation of breast cancer 4T1, MCF-7 cells, inducing apoptosis, and inhibiting tumor growth in 4T1 tumor-bearing mice (Xiao et al, 2018). Matrine can inhibit proliferation and induce cell cycle arrest and apoptosis (Zhang et al, 2012).
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