Mathematically described model of poly(glycerol maleate) cross‐linking process using triethylenetetramine addition

Abstract

AbstractRecently intensive development of tissue engineering has been noticeable. It has caused a considerable rise in scientists' interest in biomaterials, which build scaffolds. Beneficial are biocompatible and biodegradable polymers. Due to its structure, poly(glycerol maleate) (PGMal) can be such a material. The structure of this polymer has a reactive double bond group on which precious modification reactions can occur. This article aimed to optimize the process of cross‐linking PGMal using triethylenetetramine. The reaction was investigated without and with a solvent. Due to the high viscosity of the polymer, it was decided to carry out the optimisation in the solvent variant (in tetrahydrofuran). A central, compositional, two‐component plan was used to optimize the process. The optimizing value was the degree of conversion, calculated based on the proton nuclear resonance spectrum. Its maximization was sought. High‐conversion rates were obtained during the tests. The aza‐Michael addition turns out to be a priceless reaction to modify unsaturated polyesters. Selectivity is noticeable in solvent‐free variants. Complete substitution to maleic fragments and partial substitution to fumaric fragments was observed. No selectivity was observed in the presence of THF.