Abstract

The transient and steady-state release characteristics of a membrane-moderated controlled-release product have been investigated by a mathematical simulation model which takes into consideration the time-, space-, and temperature-dependent parameters. The effects of the membrane porosity, membrane thickness, storage period of the product, and the environmental temperature on both the transient and steady-state release rate have been elucidated. The experimentally determined release pattern of active agent through a bioerodible membrane, especially the effect of temperature on the release rate, has been described well by the present model.

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