Abstract
Multi-drug (or multi-element) combinations are often prescribed in the practice of clinical medicine and as foods for special medical purposes. The main motivations for these combinations are that most diseases contain multiple related targets and an appropriate combination can maximize benefits while minimizing adverse reactions. As such, it is especially important to derive mathematical models for their quantitative calculation. In this paper, we introduce mathematical rules for the synergistic, additive, and antagonistic effects of multi-drug combinations developed in our laboratory. We have established a “one-belt, one-line” model and provide examples of the quantitative calculation of the synergistic, additive, and antagonistic effects of a combination of multiple components. We also explain how to scientifically and precisely determine the intensity of these synergies, additions and antagonisms, as well as their corresponding dose ranges, thereby laying a solid theoretical foundation for market listing combinatorial drugs and foods for special medical purposes.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
