Abstract
Expanded bed adsorption (EBA) emerged in the early 1990s in an attempt to integrate the clarification, capture and initial product concentration/purification process. Several mathematical models have been put forward to describe its operation. However, none of the models developed specifically for EBA allows simultaneous prediction of bed hydrodynamics, mass transfer/adsorption and (unwanted) interactions and fouling. This currently limits the development and early optimization of EBA‐based separation processes. In multiphase reactor engineering, the use of multiphase computational fluid dynamics has been shown to improve fundamental understanding of fluidized beds. To advance EBA technology, a combination of particle, equipment and process scale models should be used. By employing a cascade of multiscale simulations, the various challenges EBA currently faces can be addressed. This allows for optimal design and selection of equipment, materials and process conditions, and reduces risks and development times of downstream processes involving EBA. © 2018 The Authors. Journal of Chemical Technology & Biotechnology published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
Highlights
The downstream processing (DSP) of biological products typically involves a sequence of unit operations to remove biomass, capture the target, purify and formulate it.[1]
Reducing the number of steps in DSP would be beneficial to the overall process economics
The aim of this paper is to provide an overview of currently available mechanistic models for Expanded bed adsorption (EBA) systems, extend this with a summary of models for liquid-solid fluidized beds (LSFBs) and propose how these models can be extended to allow for in silico optimization of EBA systems
Summary
The downstream processing (DSP) of biological products typically involves a sequence of unit operations to remove biomass, capture the target, purify and formulate it.[1]. This allows cells and debris to move through the bed relatively unhindered while the desired product is captured by means of adsorption. The technology of EBA is attractive because it fuses three unit operations (clarification, capture, concentration and partial purification) into one, promising improved overall yield.[4]
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