Abstract
The present chapter focusses on mechanistic models of mammalian cell bioprocesses used for the production of biopharmaceuticals. Different types of models can be used to simulate mammalian cells. Modelling of bioprocesses largely benefit from including kinetics, which reflects the influence of metabolites or other factors on the process variables. Due to the complexity of the kinetic models, with the challenges of determining the kinetic equation and its parameters, not to mention the risk of over-fitting, most models of mammalian cell bioprocesses have opted for a macroscopic approach for the modelling. For this, the detailed description of the intracellular phenomena is reduced or eliminated, and elementary flux mode is one of the main methods to support the creation of macroscopic models. We review how these models are built and shortly address how models are used for monitoring and process optimization.
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