Abstract
The goal of this study is the development of treatment schedules with increased selectivity in killing malignant cells as opposed to normal cells. The optimization is carried out on the basis of the mathematical model. The model describes the dynamics of proliferating cell population under in vivo periodic treatment with high doses of a phase-specific agent. On the basis of the model the effectiveness of various treatment schedules have been studied and optimal ones have been designed. When the mean cell-cycle times of normal and tumors cells differ significantly (as it is true for most natural tumors) the optimal schedules make it possible to increase considerably the selectivity of the treatment and to achieve important therapeutic benefit.
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