Mathematical Modelling of Basal Ganglia for Parkinson’s Disease: A System Biology Approach

Abstract

Objectives: To mathematically model the oscillatory behaviour of Basal Ganglia for Parkinson’s disease as well as to simulate the model by using Cell designer and Scilab. Method: The pathway of Parkinsons disease was downloaded from the KEGG database and oscillatory behaviour was studied using scilab programming and cell designer tool. In this work, the pathway of Parkinson’s disease was loaded to cell designer, that is working on the basis of systems biology mark-up language, and analysed the entire pathway. Findings: The oscillary behaviour of basal ganglia is due to the absence or lack of dopamine and it can be verified with the aid of Scilab, programming. Novelty: Through this study, the computational tool cell designer and scilab programming, was newly introduced for analysis and modelling of oscillatory behaviour of neurons. It is concluded that the pathway and simulation of all disease can be analyzed in an accurate way using this software with in a short time period. Keywords: Scilab; Cell designer; Basal ganglia; Parkinson’s disease