Abstract
Laser-induced thermotherapy (LITT) is a minimally invasive method causing tumor destruction due to heat ablation and coagulative effects. Computer simulations can play an important role to assist physicians with the planning and monitoring of the treatment. Our recent study with ex-vivo porcine livers has shown that the vaporization of the water in the tissue must be taken into account when modeling LITT. We extend the model used for simulating LITT to account for vaporization using two different approaches. Results obtained with these new models are then compared with the measurements from the original study.
Highlights
Thermal ablation methods briefly generate cytotoxic temperatures in tumorous tissue in order to destroy it
4.1 Numerical solution of the governing partial differential equation (PDE) The mathematical model for radiative heat transfer and the models for vaporization described above were used to simulate the behavior of ex-vivo porcine liver tissue during Laser-induced thermotherapy (LITT)
In this study LITT was applied to ex-vivo porcine livers and the resulting temperature was measured with a probe
Summary
Thermal ablation methods briefly generate cytotoxic temperatures in tumorous tissue in order to destroy it. These minimally invasive methods are used for treating cancer, e.g., in lung, liver, or prostate, when surgical resection is either not possible or too dangerous for the patient. The principle of LITT [1] is based on the local supply of energy via an optical fiber, located in a water-cooled applicator. This applicator is placed directly into the tumorous tissue. The patient is not exposed to radiation, in contrast to other treatments that can only be carried out under CT control
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