Mathematical modeling of tumor-immune system dynamics subject to dendritic cells immunotherapy: a brief review

Abstract

Currently, there is a promising therapy to treat cancer that uses dendritic cell infusions. Dendritic cells play a crucial role in the initiation, programming, and regulation of the specific immune response, for this reason they are considered the best antigen-presenting cells. The objective of using them in immunotherapy is to induce a specific immune response of T cells towards cancer cells. This article provides a brief review of three mathematical models of the tumor-immune system interaction subject to dendritic cell immunotherapy. It is important to point out that analyzing mathematical models is a crucial stage in the design of control laws for establishing optimal administration protocols for dendritic cell immunotherapy.