Abstract
The biodegradable polymers are widely used in therapeutic surgery and pharmaceutics, in which the degradation process has drawn significant attention in recent years. In this paper, we propose a mathematical model to predict the polymer degradation in tissue engineering applications. A stochastic model is introduced to characterize the hydrolysis reaction in an elemental basis and the mass transport is also performed to investigate the diffusive transport of polymer erosion. Two representative polymeric films in different configurations are studied. It is found that for biodegradable systems, mass transport plays an important role in controlling the erosion pathway, in which the matrix configuration could be one of the key factors that determine the characteristics of erosion and drug release rates. The proposed model makes a useful benefit to the design optimization of the matrix architectures for biodegradable devices.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
