Mathematical modeling of HIV/HTLV co-infection with CTL-mediated immunity

Abstract

In the literature, a great number of HIV and HTLV-I mono-infection models has been formulated and analyzed. However, the within-host dynamics of HIV/HTLV-I co-infection has not been modeled. In the present paper we formulate and analyze a new HIV/HTLV-I co-infection model with latency and Cytotoxic T lymphocytes (CTLs) immune response. The model describes the interaction between susceptible CD$4^{+}$T cells, latently HIV-infected cells, actively HIV-infected cells, latently HTLV-infected cells, Tax-expressing HTLV-infected cells, free HIV particles, HIV-specific CTLs and HTLV-specific CTLs. The HIV can spread by virus-to-cell and cell-to-cell transmissions, while the HTLV-I can only spread via cell-to-cell transmission. The well-posedness of the model is established by showing that the solutions of the model are nonnegative and bounded. We derive the threshold parameters which govern the existence and stability of all equilibria of the model. We prove the global asymptotic stability of all equilibria by utilizing Lyapunov function and Lyapunov-LaSalle asymptotic stability theorem. We have presented numerical simulations to illustrate the effectiveness of our main results. In addition, we have discussed the effect of HTLV-I infection on the HIV-infected patients and vice versa. We have pointed out the influence of CTL immune response on the co-infection dynamics.