Abstract
In-Vitro Dissolution Study and Shelf Life Calculation of Developed Sol-To-Gel Ocular Drug Delivery System of Brimonidine for Conjunctivitis during Accelerated Stability StudyManu Babbar, Kanchan Kohli, Anil Bhandari
Highlights
In recent decades, increasing attention has been devoted to the nanotechnology role in various sciences including biomedical and pharmaceutical fields
This study aims to provide a comparative mathematical analysis of drug molecules release from swellable polymeric drug delivery systems to find a general model the most applicable to determine the in vivo profile
The number of errors less than 5% was 46.15%of a total number of data set and akaike information criterion of this model is -34.93
Summary
In recent decades, increasing attention has been devoted to the nanotechnology role in various sciences including biomedical and pharmaceutical fields. Nanoparticles have emerged as promising carriers for the delivery of a wide range of therapeutic drugs. Many materials such as polymers, lipids, proteins, carbons, and inorganic metals are under investigation for drug delivery (Yoon et al, 2013). To improve the delivery systems, several types of nanoparticulate systems including polymeric nanoparticles (Hamidi et al, 2011; Azadi et al, 2012; Hamidi et al, 2012; Azadi et al, 2015), polymeric micelles, solid nanoparticles, lipid-based nanoparticles, such as solid lipid nanoparticles (SLN), nanostructured lipid carriers (NLC) and lipid drug conjugate (LDC) (Ashrafi et al, 2013), nanoliposomes (Azadi and Ashrafi, 2016), inorganic nanoparticles, dendrimers, magnetic nanoparticles, Ferrofluids, Azadis et al / Journal of Applied Pharmaceutical Science 7 (04); 2017: 125-133 essential determinant for designing of controlled drug release systems. This study aims to provide a comparative mathematical analysis of drug molecules release from swellable polymeric drug delivery systems to find a general model the most applicable to determine the in vivo profile
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