Abstract
Background and Aims: Transarterial-chemoembolization (TACE) and tyrosine-kinase inhibitors (TKI) represent first-line treatments in intermediate and advanced hepatocellular carcinoma (HCC). Deepening TKI and TACE response mechanisms may provide insights to optimize their combination. We developed a physic-mathematical model to analyze cancer cells and tumor vasculature dynamics in HCC patients (pts) using serum biomarkers combined with tumor digital imaging before and after TACE or TKI treatment.
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