MATHEMATICAL MODEL OF REPELLENT EFFECT IN DENGUE TRANSMISSION

Abstract

Dengue is a disease caused by the dengue virus, transmitted through the bite of an infected female Aedes aegypti. Dengue virus is a member of the genus Flavivirus, family Flaviviridae. Indonesia is one of the countries with the most dengue cases in Southeast Asia. Therefore, dengue transmission must be controlled to reduce the increase in dengue cases. One of the controls is by using repellents. Repellent is one of the human protection strategies to avoid mosquito bites used by spraying or smearing. This study models dengue transmission by reviewing the effect and control of repellent. A mathematical model of repellent effect and control in dengue transmission uses a SIR compartment model. The SIR model is modified by involving mosquitoes and the human population. Repellent is used in both susceptible humans, infected humans, and recovered humans. Numerical and analytical simulations are conducted to analyze the behavior of each compartment of the mosquito and human populations in dengue transmission. Analytical results show that the factors affecting the spread of infection are the transmission rate of the dengue virus and the loss of human-repellent protection. The transmission rate of dengue virus in the interval increases the infected human by 2.73%, while the rate of loss of human repellent protection in the interval increases the infected human by 0.03%. Optimal control is used to minimize the number of infected humans who do not use repellent. The results of numerical simulations on the optimal control problem show that an increase in the proportion of healthy humans who have campaign effect and use repellent regularly in the range of 14.67% can reduce infected individuals by 0.647%.