Abstract
A population balance equation, in which moisture content was taken into consideration for the coalescence probability of two colliding granules, was proposed to investigate the kinetics of granule growth in agitation fluidized bed granulation. The effects of operating variables such as moisture content, damping speed and operation time on the granule growth and its rate were numerically examined. It was found that the theoretical results intrinsically revealed these effects on granule size, size distribution and granule growth rate. The theory also showed good agreement with the experimental granulation data for pharmaceutical powders. As a result, the granule growth mechanism in agitation fluidized bed granulation was elucidated in detail.
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