Abstract
Mathematical Analysis of Antibody by Gamma and PSI Functions
Highlights
Mathematical or computational models have been proposed in different biological subjects in order to explain various complex phenomena
Topology knowledge can be important in antibody application as well as transformation
Topology is a powerful tool to predict the structure of protein and it will serve to antibody engineering
Summary
Mathematical or computational models have been proposed in different biological subjects in order to explain various complex phenomena. We have designed this study to monoclonal antibodies and Fc-fusion proteins (Figure 1). It is still difficult to predict the optimal structure of antibodies. Topology knowledge can be important in antibody application as well as transformation. We can obtain desired antibodies by using protein/ gene engineering technology. We could transform any domain of antibody to make it bind with any desired target. Under this vision, topology is a powerful tool to predict the structure of protein and it will serve to antibody engineering. Our present work tries to explain, and predict, if possible, the change of structure, size and function of antibodies as well as their fragments from a topological perspective
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