Mathematical analysis of a tumor invasion model—global existence and stability

Abstract

This work studies an outstanding reaction–diffusion system modeling tumor invasion, with interactions among tumor tissue, acid concentration and normal tissue. This model has very different features from the models extensively studied in the mathematics literature. The most challenge issue for mathematical analysis of the present model is the existence of classical solution, since the diffusion of tumor tissue is influenced by the density of normal cells and diffusion degeneracy arises when normal cells are at the carrying capacity. A rigorous proof of global existence and uniqueness of classical solutions is presented. Moreover, we study global dynamics of the solution, and show asymptotic stability of the four possible constant equilibria under various scenarios.