Abstract
Background Peanut allergy is known to be one of the most severe food allergies. The aim of our breast milk study was to investigate the transfer of the most potent peanut allergen Ara h 2 into human breast milk in a German cohort. Therefore, the time courses of appearance after ingestion, the potential risk of sensitization to peanuts via breast milk in Germany and, if possible, the way Ara h 2 will be processed in vivo after secretion into breast milk was studied.
Highlights
Peanut allergy is known to be one of the most severe food allergies
After maternal ingestion Ara h 2 is secreted into breast milk in our German cohort in 25 % of the volunteers, individually either rapidly or delayed and in different concentrations
To study Ara h 2 or Ara h 2 peptides that survive digestion and pass into human breast milk antibodies against the 12 kDa fragment are raised for enrichment strategies to characterize these sensitizing or tolerogenic peanut structures in our breast milk samples
Summary
Peanut allergy is known to be one of the most severe food allergies. The aim of our breast milk study was to investigate the transfer of the most potent peanut allergen Ara h 2 into human breast milk in a German cohort. The time courses of appearance after ingestion, the potential risk of sensitization to peanuts via breast milk in Germany and, if possible, the way Ara h 2 will be processed in vivo after secretion into breast milk was studied
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