Abstract
We read with great interest the Article by Tim Korevaar and colleagues showing that both high and low maternal free thyroxine in early pregnancy are associated with a signifi cant decrease in child intelligence quotient (IQ). We previously reported that thyroid function in early pregnancy in Japanese women, who generally have suffi cient iodine intake, had no relevance to parameters in neonates, scores of fetal maturation, or child development. Free thyroxine increase in early pregnancy is a physiologically adaptive change induced by circulating asialo-human chorionic gonadotropin and is associated with severity of morning sickness. Typical cases are characterised by gestational thyrotoxicosis and usually accompanied by hyperemesis gravidarum. Increased free thyroxine is often complicated by maternal malnutrition. Early fetal brain development might be aff ected by maternal nutrition and thus decreased IQ should also be assessed in relation to the possible presence of maternal nutritional disorders.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
