Maternal sleep duration and neonate birth weight: Apopulation-based cohort study.

Abstract

To investigate the association between maternal sleep duration (an important health indicator) and neonate birth weight. The study included 2536 mother-neonate pairs of a Spanish birth cohort (2004-2006, INMA project). The exposures were questionnaire-based measures of sleep duration before and during pregnancy. The primary outcome was neonate birth weight score (g) standardized to 40weeks of gestation. In women sleeping for <7h/day before pregnancy, each additional hour of sleep increased birth weight score by 44.7g (P=0.049) in the minimally adjusted model, although findings were not statistically significant after considering other potential confounders (P>0.05). However, increasing sleep duration for the group of mothers who slept for more than 9h/day decreased birth weight score by 39.2g per additional hour (P=0.001). Findings were similar after adjusting for several sociodemographic confounders and maternal depression-anxiety clinical history as an intermediate factor. Similar but attenuated associations were observed with sleep duration in the second trimester of pregnancy. The relationship between maternal sleep duration before and during pregnancy and neonate birth weight is an inverse U-shaped curve. Excessive sleep duration may adversely affect neonate health through its impact on birth weight.