Year-end Sale % OFF 
Abstract
Maternal Vitamin B12 deficiency during pregnancy is associated with offspring neuropsychiatric disorders. Few previous studies examining this association with attention-deficit/hyperactivity disorder (ADHD) report inconsistent findings. The study examines the association between maternal serum Vitamin B12 levels and offsprings’ risk of ADHD. This study is based on the Finnish Prenatal Study of ADHD with a nested case–control design. All the singleton children born in Finland between January 1998 and December 1999 and diagnosed with ADHD were included in the study. A total of 1026 cases were matched with an equal number of controls on sex, date of birth and place of birth. Maternal Vitamin B12 levels were assessed using a chemiluminescence microparticle immunoassay and archived from maternal serum banks, collected during the first and early second trimester of pregnancy. Lower maternal Vitamin B12 levels when analyzed as a continuous variable was not associated with offspring ADHD (aOR 0.97, 95% CI 0.79–1.18, p = 0.75). No significant associations were seen in the lowest quintile of Vitamin B12 levels (aOR 0.96, 95% CI 0.73–1.27, p = 0.80). This is the first study examining maternal sera Vitamin B12 levels during early pregnancy and offspring ADHD. The result suggests that Vitamin B12 deficiency during early pregnancy has specificity for some disorders but not with offspring ADHD.
Highlights
Attention-deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder characterized by symptoms of hyperactivity, impulsivity, and inattention [1]
Evidence linking maternal nutrition and neuropsychiatric disorders in children has been shown in the Dutch and the Chinese famine studies in which maternal exposure to famine resulted in offspring schizophrenia [8,9,10,11,12] and depression [13, 14]
There was no significant association observed between maternal Vitamin B12 and offspring ADHD
Summary
Attention-deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder characterized by symptoms of hyperactivity, impulsivity, and inattention [1]. Maternal nutrition is critical for fetal growth and development [15], and prenatal nutritional deficiency during a critical phase of brain development may result in irreversible functional changes to the brain, predisposing children to neurodevelopmental disorders [16, 17]. Several nutrient deficiencies such as folate, polyunsaturated fatty acids and minerals like iron and iodine in early pregnancy have been reported to negatively impact cognitive and behavioural outcomes of
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
