Maternal serum inhibin-A for predicting preeclampsia

Abstract

Objective. To evaluate the use of late first trimester maternal serum inhibin-A concentrations in prediction of preeclampsia.Design. Prospective study.Setting. Tanta University Hospital.Methods. All cases (327) were subjected to complete history taking, clinical and ultrasound examination, CBC, liver function tests, estimation of 24 h urine protein and venous blood samples were taken during the late first trimester for estimation of serum level of inhibin-A.Results. First trimester maternal serum inhibin-A concentrations were significantly higher in women who subsequently develop preeclampsia than the corresponding values in healthy matched control pregnant women.Conclusions. Measurement of inhibin-A during late first trimester of pregnancy can be useful in the prediction of preeclampsia.