Maternal serum concentrations of selected elements in pregnancies complicated with preterm prelabor rupture of membranes

Abstract

Aim: To measure maternal blood elements namely, antimony (Sb), aluminum (Al), arsenic (As), cadmium (Cd), chromium (Cr), cobalt (Co), copper (Cu), manganese (Mn), mercury (Hg), molybdenum (Mo), nickel (Ni), lead (Pb), tin (Sn), and zinc (Zn) in pregnant women complicated by preterm prelabor rupture of the membranes (pP-ROM) and to compare the results with healthy controls.
 Materials and Methods: Maternal blood concentrations of Al, As, Cd, Co, Cu, Cr, Hg, Mn, Mo, Ni, Pb, Sb, Sn, and Zn were evaluated in the pP-ROM group, which included fifty-five pregnant women complicated with pP-ROM and sixty healthy participants (control group) with respect to gestational weeks and maternal age. The maternal blood concentrations of these elements in both groups were measured using an ICP-MS and also compared. 
 Results: No significant differences regarding gestational week, BMI, parity, gravidity, and maternal age were observed (p≥0.05). The meYan blood white blood cell concentration was higher in the pP-ROM group compared to healthy controls (12.2 ± 3.5 µL/mL vs. 10.1 ± 2.6 µL/mL, respectively; p=0.001). The mean C-reactive protein concentration was higher in the pP-ROM group than the healthy group (0.99 ± 1.47 mg/ Lt vss.. 0,40±0,27 mg/ Lt, respectively; Pp=0.003). There were no differences in terms of mean maternal serum concentrations of Al, As, Cd, Co, Cu, Cr, Hg, Mn, Mo, Ni, Pb, Sb, Sn, and Zn between the study and contrrol grup (P≥0,05).
 Conclusion: These elements in maternal blood are not involved in the pathogenesis of pP-ROM.