Maternal serum 25-hydroxy vitamin D level in first-trimester pregnancy loss

Abstract

Aim: Pregnancy loss (abortus) is defined as loss of fetal cardiac beat or expulsion of pregnancy material before 20 weeks.It has many causes such as chromosomal abnormalities, uterine anomalies, infections, and unknown causes. Vitamin D has become one of the new topics of research in many medical fields, as it has relations with other diseases besides bone diseases. In some studies of recurrent pregnancy loss, a low vitamin D level was found. In our study, vitamin D levels were measured in the first-trimester pregnancy loss and normal pregnancy group. Methods: Patients, single pregnancies with a positive fetal heartbeat, who applied to the pregnant outpatient clinic for the first examination of pregnancy were included in the study, and vitamin D levels were measured at this time. The patients were followed up to the 12th gestational week using the hospital automation system. The groups of normal pregnancy and abortus groups were determined. 25-hydroxy (25-OH) vitamin D levels between 2-96 ng/ml can be detected, while over 30 ng/ml is sufficient, 20-29.99 ng/ml is insufficient, and <20 ng=''/ml is defined as a low 25(OH)D3 level. Results: 66 patients were included in the pregnancy loss group, in the follow-up, 63 patients were in the normal pregnancy group. The mean vitamin D level of the individuals included in the study was measured as 7.45�4.64 ng/ml. Levels of vitamin D were 10.04�6.19 in the normal course group and 4.8�1.73 ng/ml in the intrauterine exitus group (p<0.05). At='' a='' vitamin='' D='' level='' of='' 6,87='' ng=''/ml, pregnancy loss was expected with 90% sensitivity and 64% specificity. Conclusion: It is still an important issue to determine the most appropriate level and preconceptional starting and the appropriate dose for maximum benefit for mother and baby, especially in the reproductive period and pregnant. Therefore, large-scale randomized controlled studies of high quality are needed.