Abstract
A growing body of evidence has clearly demonstrated that maternal nutrition can strongly determine the susceptibility to the development of metabolic diseases in offspring. With the increasing prevalence of maternal overweight, obesity, and gestational diabetes mellitus, it yields enormous burden for individual and public health. Interventions during pregnancy have been proven to be challenging, with limited efficacy and low compliance. Resveratrol, as a natural polyphenolic compound, has a wide-range of beneficial properties, including potent antiobesogenic, antiatherosclerotic, and antidiabetic effects. However, the role of maternal resveratrol intake on metabolic health in offspring has not been extensively investigated. Therefore, the aim of this study was to review the effects of maternal resveratrol supplementation on metabolic health in offspring and its potential mechanisms.
Highlights
The incidence of obesity and diabetes is increasing rapidly, placing a huge economic burden on society [1]
Approximately one in six births is affected by gestational diabetes mellitus (GDM) reported by International Diabetes Federation Atlas in late 2017 [1]
As demonstrated by the “Developmental Origins of Health and Disease (DOHaD)” theory [6,7], obese mothers and women with GDM are associated with infant weight z-scores at birth and at 6 months [8], childhood obesity [9], and unhealthy body composition in adult offspring [10,11]
Summary
The incidence of obesity and diabetes is increasing rapidly, placing a huge economic burden on society [1]. One clinical study was conducted to evaluate the metabolic effects of resveratrol in overweight pregnant women It showed that resveratrol supplement (80 mg) reduced the incidence of GDM and improved the lipid profile and glucose blood level after 60 days [41]. GDM, it showed that resveratrol intake (10 mg/kg body weight per day) before pregnancy and during pregnancy significantly alleviated hyperglycemia, improved insulin resistance, increased fetal survival, and decreased body weight at birth They further found that resveratrol enhanced adenosine monophosphate activated protein kinase (AMPK) activation and reduced glucose-6-phosphatase activity in pregnant C57BL/KsJ-Leptin (db/+) mouse, as well as the offspring [44]. Resveratrol administration (100 mg/kg body weight) from embryonic day 3 to 12 prevented the occurrence of oxidative stress and apoptosis in embryos; it further decreased blood cholesterol level by 41.74% and triglyceride level by 60.64% in diabetic dams [50] It indicated that maternal resveratrol intake was able to improve lipid metabolism in both dams and offspring.
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
