Abstract
Maternal plasma 25‐hydroxyvitamin D concentration and birthweight, growth and bone mineral accretion of Gambian infants
Highlights
Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation
The circulating plasma concentration of 25-hydroxyvitamin D (25OHD), a long-lived metabolite of vitamin D, is used to judge vitamin D status; values below 25 nmol ⁄ L are associated with an increased risk of rickets and osteomalacia [1]
Positive associations have been reported between maternal vitamin D status in pregnancy and birthweight, birth length, length at 1 year and bone mineral accretion at 9 years [2,3,4,5,6], evidence is conflicting [7,8]
Summary
Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation. There is evidence that a low maternal plasma 25OHD in pregnancy may influence the growth and bone mineral accrual of the offspring during foetal life, infancy and childhood. These relationships have been observed at concentrations of 25OHD higher than those associated with rickets and osteomalacia, and there are calls to raise the accepted lower threshold of vitamin D sufficiency for pregnant women, most recently to 80 nmol ⁄ L [9].
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