Abstract
BackgroundHistological chorioamnionitis (HCA) is one of the leading causes of spontaneous preterm birth, thus, to identify novel biomarkers for the early diagnosis of HCA is in a great need.ObjectiveTo investigate the diagnostic value of maternal peripheral blood platelet‐to‐white blood cell ratio (PLT/WBC) and platelet (PLT) counts in HCA‐related preterm birth.MethodsA total of 400 patients with preterm birth were enrolled in this study: non‐HCA group (n = 193) and HCA group (n = 207), and 87 full‐term pregnancies were enrolled as the control. The peripheral blood of the participators was collected, and the neutrophil count, WBC count, platelet count, and levels of C‐reactive protein (CRP) and procalcitonin were recorded, and the platelet‐to‐white blood cell ratio (PLT/WBC) of the participators was calculated. Receiver operating characteristic (ROC) curve has been drawn to show the sensitivity and specificity of PLT/WBC and PLT count for the diagnosis of HCA‐related spontaneous preterm birth patients.ResultsThe neutrophil count, WBC count, and procalcitonin show no significant differences among the three groups, and the PLT count, PLT/WBC, and CRP (P < 0.05) were significantly increased in HCA group compared with non‐HCA group; moreover, the area under the curve (AUC) of PLT/WBC, PLT, and CRP was 0.744 (95% confidence interval [CI], 0.6966‐0.7922), 0.8095 (95% CI, 0.7676‐0.8514), and 0.5730 (95% CI, 0.5173‐0.6287), respectively.ConclusionPlatelet count and PLT/WBC may become a potential biomarker of HCA‐related spontaneous preterm birth.
Highlights
Preterm birth is a common obstetrical dis‐ order characterized by premature delivery of the infant at
Results from previous studies indicated that if no proper medical interventions were made at the early stage of cho‐ rioamnionitis, premature delivery of the babies from mothers with chorioamnionitis can lead to short‐term and long‐term complications, that is, bronchopulmonary dysplasia (BPD), cerebral palsy (CP), and early‐onset sepsis (EOS).[9,10]
While clinical chorioamnionitis can be characterized by maternal fever and other symptoms, for example, maternal leukocytosis (>15 000 cells/mm3) and maternal tachycardia (>100 bpm), there are no obvious early symptoms for Histological chorioamnionitis (HCA), as a result, to identify novel biomarkers for the early diagnosis of HCA in preg‐ nant women is of great importance for the prevention of spontaneous preterm birth
Summary
Histological chorioamnionitis (HCA) is one of the leading causes of spontaneous preterm birth, to identify novel biomarkers for the early diagnosis of HCA is in a great need. Objective: To investigate the diagnostic value of maternal peripheral blood platelet‐ to‐white blood cell ratio (PLT/WBC) and platelet (PLT) counts in HCA‐related preterm birth. The peripheral blood of the participators was collected, and the neutrophil count, WBC count, platelet count, and levels of C‐reactive protein (CRP) and procalcitonin were recorded, and the platelet‐to‐white blood cell ratio (PLT/WBC) of the participators was calculated. Receiver operating characteristic (ROC) curve has been drawn to show the sensitivity and specificity of PLT/WBC and PLT count for the diagnosis of HCA‐related spontaneous preterm birth patients. KEYWORDS blood platelet‐to‐white blood cell ratio, diagnosis, histological chorioamnionitis, platelet count, preterm birth
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