Abstract
The coronavirus infection (Covid-19) leads to overactive immune responses, resulting in oxidative stress (OS), excessive reactive oxygen/ nitrogen (ROS/RNS) production, reduced antioxidant enzymes, and disrupted total redox balance. Pregnant women are more susceptible to respiratory pathogens, i.e. to Covid-19. The aim of the study was to investigate the effects of symptomatic Covid-19 during pregnancy on oxidative/antioxidant status in blood during pregnancy and the consequences for the mother. The patients were divided: 1) Controls (n = 100); singleton pregnancy, without Covid-19; and 2) Covid-19 group (n = 65), singleton pregnancy, with symptomatic Covid-19 (>30 gestational weeks). Serum superoxide dismutase (p < 0.01), catalase (p < 0.01), protein carbonylation (p < 0.001), ROS production (p < 0.01) and albumin oxidation (p < 0.05) were increased in symptomatic Covid-19 pregnancies vs. controls. The increased maternal OS/ redox imbalance in pregnant mothers with symptomatic Covid-19 could be associated with preterm labour.
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