Maternal overnutrition elevates offspring's blood pressure-Asystematic review and meta-analysis.

Abstract

BackgroundMaternal overnutrition during pregnancy predisposes the offspring to cardiometabolic diseases.ObjectivesThis systematic review and meta‐analysis aimed to investigate the association between maternal overnutrition and offspring's blood pressure (BP) and the effect of offspring's obesity on this association.Data sourcesPubMed, EMBASE, Clinicaltrials.gov, CENTRAL.Study selection and data extractionHuman studies published in English before October 2021 were identified that presented quantitative estimates of association between maternal overnutrition just before or during pregnancy and the offspring's BP.SynthesisRandom‐effect model with the DerSimonian and Laird weighting method was used to analyse regression coefficients or mean differences.ResultsAfter selection, 17 observational studies (140,517 mother‐offspring pairs) were included. Prepregnancy body mass index (ppBMI) showed positive correlation with BP in offspring (regression coefficient for systolic: 0.38 mmHg per kg/m2, 95% confidence interval (CI) 0.17, 0.58; diastolic: 0.10 mmHg per kg/m2, 95% CI 0.05, 0.14). These indicate 1.9 mmHg increase in systolic and 0.5 mmHg increase in diastolic BP of offspring with every 5 kg/m2 gain in maternal ppBMI. Results on coefficients adjusted for offspring's BMI also showed association (systolic: 0.08 mmHg per kg/m2, 95% CI 0.04, 0.11; diastolic: 0.03 mmHg per kg/m2, 95% CI 0.01, 0.04). Independent from ppBMI, gestational weight gain (GWG) showed positive correlation with systolic BP (systolic BP: 0.05 mmHg per kg, 95% CI 0.01, 0.09), but not after adjustment for offspring's BMI. Mean systolic BP was higher in children of mothers with excessive GWG than in those of mothers with optimal GWG (difference: 0.65 mmHg, 95% CI 0.25, 1.05).ConclusionsIndependent from offspring's BMI, higher prepregnancy BMI may increase the risk for hypertension in offspring. The positive association between GWG and offspring's systolic BP is indirect via offspring's obesity. Reduction in maternal obesity and treatment of obesity in children of obese mothers are needed to prevent hypertension.