Maternal occupational exposure to carbonaceous nanoscale particles and neurodevelopmental outcomes in early childhood: Analysis of the French Longitudinal Study of Children – Elfe study

Abstract

ObjectiveTo investigate the association between occupational exposures to carbonaceous unintentionally emitted nanoscale particles (UNPs) during pregnancy and the child's language development and behaviour at two years old. MethodsUsing data from the French Longitudinal Study of Childhood - ELFE, we selected mothers who worked during pregnancy and their children. Exposure to carbonaceous UNPs was assessed by the MatPUF (job-exposure matrix for ultrafine particles). Children's lexical development was analysed using ‘the Mac Arthur - Bates communicative development inventories-words and sentences-short form’ (MB-CDI) in a multivariate binary logistic regression. Their risk for autism spectrum disorders was studied using ‘the Modified-CHecklist for Autism in Toddler’ (M-CHAT) according to the recommended thresholds (low risk = 0–2; intermediate risk = 3–6 and high risk = 7–23) in unordered multinomial logistic regression models. ResultsMaternal occupational exposure to carbonaceous UNPs was associated with delayed child language development (ORadj: 1.34; 95 % CI: 1.00, 1.80) but not with behavioural disorders (autism spectrum disorders) at two years old. ConclusionThis is the first epidemiological study to show a significant association between maternal occupational exposure to carbonaceous nanoscale particles and child language development at 2 years old.