Abstract

Consumption of high-fat diet induces liver and metabolic complications such as metabolic syndrome (MS). We previously reported that maternal MS and hypertension (HTN) dysregulate fetal and placental glucose homeostasis, which was ameliorated by inositols (INO) supplementation during pregnancy. 5' AMP-activated protein kinase (AMPK) pathway plays a key role in maintaining energy balance and glucose metabolism at liver level. We aim to investigate the effect of INO supplementation on AMPK pathway in female offspring born to a murine model of MS.

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